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Bone marrow impairment Anticancer agents can disrupt the bone marrow's capacity to generate blood cells, potentially causing conditions, such as anemia, thrombocytopenia (low platelet count), or leukopenia (low white blood cell count)

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In addition, (iv) the isocitrate dehydrogenases IDH1 and IDH2, which are located in the cytosol and mitochondria, respectively, are involved in NADPH production, and (v) glutamine metabolism is involved in NADPH generation through the glutamate dehydrogenases GDH1 and GDH2 in mitochondria