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doi: 10.1111/j.1398-9995.1990.tb00528.x

J Neuropathol Exp Neurol 49:591599

Another study showed that DFO could suppress excessive collagenase-mediated type II collagen cleavage and protease, production of cytokine, and COL10A1 expression while upregulating adenosine monophosphate-activated protein kinase and Krebs cycle genes in human osteoarthritic cartilage [125]

It is worth noting a point of ongoing scholarly discussion around this origin story: BPC-157, as studied, is a fully synthetic sequence, and its status as a naturally occurring fragment of a larger native protein has been questioned in later reviews