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To demonstrate the finding of a previously unknown transsulfuration reaction distinct from the known ligation reaction, we first examined the isotopologue patterns of key metabolite substrates such as glutamate, glycine, serine, and cysteine in 293T cells labeled by a mixture of isotopic tracers ([U- 13 C]-glutamine, [U- 13 C]-glucose, and [U- 13 C]-acetate) (Fig

13 As with joint hypermobility, hypermobility spectrum disorders can be subcategorised into: Generalised HSD (G-HSD) : symptomatic generalised joint hypermobility Peripheral HSD (P-HSD): symptomatic peripheral joint hypermobility (hands/feet) Localised HSD (L-HSD): symptomatic localised joint hypermobility, and Historical HSD (H-HSD): Historical joint hypermobility with musculoskeletal symptoms

This is consistent with the reported contribution of the IGF axis to ICB resistance 19 , although re-testing in larger cohorts will be required to confirm this finding

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