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Retatrutide: Complication Focus TRIUMPH-4: Obesity + knee osteoarthritis (445 participants) TRIUMPH-2: Obesity + type 2 diabetes TRIUMPH-6: Weight maintenance trial Advantage: Multiple complication-specific trials could lead to broader label (obesity + OA + OSA indications)

BPC-157 use may be shorter, particularly if the primary goal is GI support during titration (which may last 8 to 16 weeks) or a defined musculoskeletal recovery period

It has been reported that KIM-1 mediates fatty acid uptake by proximal tubular cells and induces cell death, mitochondrial fission and the DNA damage response in these cells (34)