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In mammals, PPP occurs in the cytoplasm of cells in various organs, including the liver, mammary glands, and adrenal glands, where it plays a vital role in generating high levels of NADPH required for biosynthetic processes (Figure 2) (Warburg and Christian, 1931

median placebo : 386 mol/L, P 0.68) (Table 2B)

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Clinical Diabetes, 28 (4), 147155

Metabolic Pharmaceuticals' Phase 2 clinical trial tested multiple doses (1mcg/kg up to 400mcg/kg, as well as fixed doses of 1mg/day) in obese patients