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The problem is that our B12 levels naturally decline with age, making it that much more difficult to keep our B12 levels healthy, and that much more important to supplement with B12 as we age

Cortisol interferes with collagen synthesis, reduces immune function, and shifts metabolism away from repair processes

To increase the amount of ATP, the cell transcribes the nuclear genes encoding mitochondrial proteins (NuGEMPs) which in turn promote the activity of the outer mitochondrial membrane (OMM) proteins, Mitofusin 1 and 2 (Mnf1/2) and the inner mitochondrial membrane (IMM) protein, Optic Atrophy Protein 1 (Opa1) ( On the other hand, under conditions of reduced energy demand or in the presence of dysfunctional mitochondria, such as during a sedentary lifestyle or aging, the fission mechanism (the removal of a mitochondria) is enhanced ( These mechanisms are also influenced by mitochondrial DNA (mtDNA)

So that's a chronically ill man

However, Medeiros et al