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Glossary AIDs autoimmune diseases RA rheumatoid arthritis SLE systemic lupus erythematosus MS multiple sclerosis DM dermatomyositis HIF hypoxia-inducible factor PGK phosphoglycerate kinase LDHA lactate dehydrogenase A pVHL the tumor suppressor protein Von Hippel-Lindau Tumor Suppressor Protein VEGF vascular endothelial growth factor ODD oxygen-dependent degradation domain PHDs prolyl hydroxylases Ub ubiquitin proteins FIH factor-inhibiting HIF TAD transactivation domain HREs hypoxic response elements GLUT1 glucose transporter 1 EPO erythropoietin MAPK mitogen-activation protein kinase ERK extracellular protein kinases EGF epidermal growth factor IGF-1 insulin-like growth factor-1;PI3K, phosphoinositide 3-kinase PKB/AKT protein kinase B mTOR the mechanistic target of rapamycin kinase STAT3 signal transducer and activator of transcription 3 AMPK AMP-activated protein kinase JAK Janus tyrosine kinase NLRP3 nucleotide-binding oligomerization structure-like receptor family pyrin domain protein 3 Treg regulatory T cells TNF- tumor necrosis factor TAK1 transforming growth factor-activated kinase 1 HMGB1 hypoxia-induced high mobility group proteins 1 JNK c-Jun N-terminal kinase SIRT silence information regulator Ang1 angiopoietins1 PDGF-BB platelet-derived growth factor-BB IL-1 interleukin-1 ROS reactive oxygen species NF-B nuclear factor kappa-B GRK2 G protein-coupled receptor kinase 2 PDK1 phosphoinositide-dependent protein kinase-1 ATP adenosine triphosphate NETs neutrophil extracellular traps GM-CSF granulocyte-macrophage colony stimulating factor BLyS B-lymphocyte stimulator DMARDs disease-modifying anti-rheumatic drugs LPS lipopolysaccharide SS Sjgrens syndrome LncRNA Dpf3 long non-coding ribonucleic acid Dpf3 microRNA micro-ribonucleic acid RORt RAR-related orphan receptor gamma t MDSCs myeloid-derived suppressor cells SPNTi sono-activatable semiconducting polymer nanopartners SDT sonodynamic therapy TPZ tirapazamine ICD immunogenic cell death MLS macrophage-like synoviocytes FLS fibroblast-like synoviocytes CIA collagen-induced arthritis model OA osteoarthritis EndoMT endothelial-to-mesenchymal transition CXCL12 chemokine (C-X-C motif) ligand 12 OCs osteoclasts ANGPTL4 angiopoietin-like 4 OBs osteoblasts RANKL receptor activator of NF-B ligand MMP2 matrix metalloproteinase 2 DEX Dexamethasone ART artesunate RBA roburic acid RIPK3 receptor-interacting protein kinase 3 IECs intestinal epithelial cells LN lupus nephritis PLN proliferative lupus nephritis mtROS mitochondrial ROS RET reverse electron transfer mTORC1 mTOR complex 1 MRL/lpr mice metabolic reprogramming in lupus-prone mice ECM extracellular matrix TGF- transforming growth factor- jDM juvenile DM RIG-I retinoic acid-inducible gene I HLA-B27 human leukocyte antigen-B27 HBOT hyperbaric oxygen therapy PIGF placental growth factor SDF-1 stromal cell-derived factor-1 S1P sphingosine-1-phosphate MAN -mangostin iNOS inducible nitric oxide synthase AIA antigen-induced arthritis FKBP12 FK506 binding protein 12 ITP immune thrombocytopenia NAC N-acetylcysteine GSH glutathione GSSG oxidized glutathione disulfide TAC the total antioxidant capacity NRF-2 NF-E2-related factor-2 KEAP-1 kelch-like ECH-associated protein 1 HO-1 heme oxygenase 1 EVOO extra virgin olive oil AP1 activator protein-1 DNA deoxyribonucleic acid LDH lactate dehydrogenase NDUFA4L2 NADH dehydrogenase (ubiquinone)-1 EAE experimental autoimmune encephalomyelitis

The biggest culprits are smoking, chronic poor sleep, sedentary lifestyle, and unmanaged chronic stress

Angot E, Steiner JA, Tom CML, Ekstrm P, Mattsson B, Bjrklund A, et al

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As a result, collagen levels rise, enhancing skin suppleness and minimising wrinkles (1)