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10.3390/biomedicines13010018 24 De RosaS

Transcriptional regulation by Nrf2

doi: 10.1101/gad.13.1.76

All mice were housed in groups of 35 per cage at a standard temperature (23 C) and humidity (4060%)-controlled environment on a 12 h light/dark cycle

The phosphatidylinositol 3-kinase (PI3K)/AKT and Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling pathways were hindered, and the p38-MAPK pathway was promoted under these conditions, resulting in G1 phase arrest and autophagy in the osteoblast cell line MC3T3-E1 (Cen et al., 2018)