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Considering the chelation ability of ALN, Chen and colleagues prepared a cellular drug delivery system based on ALN-containing liposomes loaded with an anti-osteosarcoma drug (methotrexate, MTX) for precise targeting of bone diseases, thereby achieving effective inhibition of osteosarcoma in situ ( 2.3 Proteins Recently, significant progress has been evidenced by delivering small-molecule drugs using proteins to improve both the efficacy and safety during cancer therapy (Wang S

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