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doi: 10.1016/j.neuint.2023.105585 12 LiSWangYWuMYounisMHOlsonAPBarnhartTEet al

Research has shown that it might be beneficial in cases of infertility, but based on the currently available data, it cannot be considered safe for use while one is pregnant or nursing

Common underlying conditions include rheumatoid arthritis, inflammatory bowel disease, chronic infections, and cancer when the anemia is disease-related rather than chemotherapy-related

Further studies have established that APR-246 can also trigger p53-independent cell death in several solid cancers, suggesting that besides p53, other cellular targets might be involved in APR-246 effect [56]