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10.1016/j.jot.2020.09.006 273 YinB.XuJ.LuJ.OuC.ZhangK.GaoF.et al (2024)

When exposed to oxidative stress like drugs, toxic chemicals, disease, aging, stress, glutathione levels drop

In a randomized control trial, valproate alone was found to show poorer outcomes for infants than valproate plus levetiracetam in terms of reduction of seizures, freedom from seizures, daily living ability, quality of life, and cognitive abilities

Multivariate analysis was performed to identify interactions and changes in the overall metabolome profile of WT and gsh2 mutant strains, as well as supernatant and cellular extract fractions

This effect of RRM1 silencing on erastin2-induced ferroptosis was specific: RRM1 silencing did not inhibit cell death in response to several mechanistically distinct small molecule inducers of apoptosis or other forms of non-apoptotic cell death that are not directly linked to intracellular GSH metabolism (Ko et al, 2019) (Fig S4A)