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Anti-TPO positivity was found in 69% and 65% of individuals before the detection of ANA and anti-ENA, respectively

In summary, bidirectional DNA methylation regulation outlines the genome-wide epigenetic landscape of malignant progression of thyroid cancer, covering the inactivation of tumor suppressor genes (such as PTEN, RASSF1A) and the abnormal activation of oncogenes (such as TERT, PLAU)

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