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9 Tolerability, safety and regulatory considerations Preclinical investigations consistently demonstrate that luteolin is well tolerated across multiple experimental systems

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However, supplementing cell-permeable dimethyl succinate (DM-succinate) at similar doses to -KG failed to rescue any cell death (Extended Data Fig

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Enzymatic degradation of the glycocalyx is mediated by catabolic enzymes, catabolites, metalloproteinases, matrix metalloproteinases (MMPs), disintegrin and metalloproteinase domain-containing proteins (ADAMs), heparanase-1, hyaluronidase, and GPI-specific PLC AMs (6163)