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Moreover, when administered orally, berberine has been shown to exhibit a wide therapeutic safety margin

Discov Med 17(93):121130 Powers SK et al (2022) Exercise training and skeletal muscle antioxidant enzymes: an update

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The brain and gut communicate constantly through the vagus nerve, meaning gastrointestinal discomfort during opiate withdrawal can further intensify anxiety and emotional distress through bidirectional neural signaling