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Each approach is tailored to individual skin types, medical history, and the underlying mechanism driving pigment irregularity whether dullness, sun damage, or deeper dermal melanin deposits

The study was conducted on 32 male mice divided into four groups: a control (C) group receiving a standard diet with biotin, a biotin-deficient (BD) group on a biotin-free diet, a ketogenic control (KC) group on a ketogenic diet (low-carbohydrate and high-fat) with biotin, and a ketogenic biotin-deficient (KBD) group on a ketogenic diet without biotin

Harman and Blackman, 2004)

Additionally, molecular docking analyses revealed strong binding interactions between CA II and major phenolic compounds in the extracts, such as cyanidin-3-O-glycoside and rosmarinic acid