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This involves direct harm to neurons due to hypoxia and subsequent inflammatory responses

A lot of the complications of diabetes, such as cardiovascular disease, retinopathy, and kidney problems, are actually caused by the accumulation of AGES.[ref] Preventing the formation of AGEs in the body: The glucose metabolites that react to form AGEs can be stopped in multiple ways in the body

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These data link NF1 deficiency to fundamental shifts in muscle metabolism, and provide strong proof of principle that a dietary intervention can ameliorate muscle symptoms