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Obes Rev 13(3):275286

Furthermore, FMO3 is regulated by farnesoid X receptor (FXR), a nuclear receptor activated by bile acid (Lefebvre et al., 2009), and injection of FXR ligands induced the expression of FMO3 and the production of TMAO in mice ( TMAO levels were significantly associated with body mass index (BMI) in healthy adults with different risk factors (Wang et al., 2016), and studies in humans and mice have shown that plasma TMAO levels increased with ageing (Wang et al., 2014

BACKGROUND.l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis in mice via gut microbiotadependent formation of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) via a multistep pathway involving an atherogenic intermediate, -butyrobetaine (BB)