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Conversely, liver damage or dysfunction can also affect the storage and utilization of B12, possibly contributing to low B12 levels

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Unlike glucose and glutamine, which are taken up by their corresponding transporters, imported cystine must first be reduced to cysteine ( via glutaminase and serves as a precursor for GSH synthesis, in addition to a role in the tricarboxylic acid (TCA) cycle (via conversion to -ketoglutarate) ( Figure 2 Many studies indicate that several SLC7A11-high cancers are sensitive to glucose deprivation, however the exact mechanism here remains an active area of research

At the time of recording this episode, we discussed some of those as being recently banned by the FDA

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