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Retinoic acid is the form that does the work, binding to retinoid receptors (RAR and RXR) in cell nuclei and directly regulating gene expression

Hypoxia induces the overexpression of Hilpda, which leads to triglyceride overload and FAO defects by downregulating adipose triglyceride lipase (ATGL), triggering mitochondrial dysfunction and upregulating profibrotic factors (TGF-1, -SMA, type I collagen) while reducing the expression of cyclin-dependent kinase 1 (CDK1) and increasing the CyclinB1/D1 ratio, collectively promoting renal tubular fibrosis [85]

Lau, David C W

Analysis of tobacco exposures and high-risk HPV infection in american women: national health and nutrition examination survey

To overcome this limitation and develop new therapeutic strategies, generating an experimental model reflecting human renal Fabry disease is essential