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Colchicine-loaded hydrogel microneedles demonstrate prolonged anti-inflammatory efficacy by downregulating pro-inflammatory cytokines (IL-1, IL-6, and TNF-) and reducing neutrophil infiltration in gouty joints, as evidenced in rat arthritis models (Jiang et al., 2023)

Nevertheless, renal clearance and absorption of carnitine were not investigated in our study

And B55 is specifically induced by glutamine deprivation in a ROS-dependent manner to activate p53 via direct interaction and dephosphorylation of EDD (a B55-interacting protein) and to promote cell survival[58]