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doi: 10.1172/JCI42447 35 SotiropoulosAOhannaMKedziaCMenonRKKopchickJJKellyPAet al

Given that NNMT has been reported to be a primary metabolic enzyme[36] and a major clearance pathway for intracellular NA,[15] it is likely that these small molecules are directly and selectively inhibiting the conversion of NA to 1-MNA