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Their "integrated trigger point hypothesis" describes an energy crisis at the motor endplate (the junction where nerve meets muscle)

Although exact rankings shift year-to-year, these categories dominate prescription volume

Treatment options can include: Supplements Oral B12 : Effective for most people, even those with mild malabsorption Sublingual B12 : Dissolves under the tongue, dominantly orally with some absorption passing into the bloodsteam Injectable B12: Used in specific cases, for example if someone is not responding to oral or sublingual supplements

Diet Vitamin B12 is mainly found in animal-based foods so individuals who follow a strict plant-based diet are at a higher risk of developing a vitamin b12 deficiency

These include TNF-alpha, IL-1 beta, and IL-6, all of which drive joint destruction in inflammatory arthritis