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Supporting the genetic basis of these associations, a recent hospital-based case-control study in Korean women identified variants in the melatonin receptor gene MTNR1A that were linked to BC risk, with certain polymorphisms interacting with NSW to further elevate susceptibility, highlighting a gene-environment interplay in circadian disruption-mediated breast carcinogenesis 195

Studies have shown that the level of -262C/T polymorphism effects not only the transcriptional activity but also the level of catalase in red blood cells [37]