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Int J Mol Sci 23:4259

Padilla et al (142) used humanized mouse models to investigate the mechanisms by which disrupted circadian rhythms contribute to NAFLD-associated HCC development

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This redox state change of GPX4 is associated with a change between the reduced form GSH or the oxidized GSH disulfide form/GSSH, which ultimately converts toxic PLOOH to chemically inert lipid alcohols/PLOH [85]