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This reliance significantly complicates the establishment of causal mechanisms and limits the translational potential of these findings

More importantly, oxidant enzymes including mitochondrial electron transport chain complex I, complex II, complex III, as well as SODs, xanthine oxidase (XO), NO synthases (NOS), cytochrome p 450 enzymes (CYP), NADPH oxidases (NOX) and lipoxygenase (LOX), generate O 2 radicals which are quickly converted into H 2 O 2 , OH and other radicals [26]

Thrombophilia is a condition predisposing to venous thromboembolism (VTE or thrombosis) due to hematological changes and can be inherited or acquired

doi: 10.1080/09674845.2007.11732754

Federici L, Lo Sterzo C, Pezzola S, Di Matteo A, Scaloni F, Federici G et al