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Hypoxia stabilizes HIF-1, enabling its nuclear translocation and activation of hypoxia-responsive genes, including those involved in autophagy

Since the pentose phosphate pathway is virtually its sole means of producing NADPH, the red blood cell is very sensitive to oxidative damage if the function of this pathway is impaired (eg, by enzyme deficiency)

Studies focus on how Cartalax supports cartilage cell signaling linked to matrix balance

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[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Cesar L.B., Gojkovic S., Krezic I., Malekinusic D., Zizek H., Vuletic L.B., Petrovic A., Pavlov K.H., Drmic D., Kokot A., et al