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Cardiovascular safety of oral p-synephrine (bitter orange) in healthy subjects

The increased fat mass increases FFA availability, inducing insulin resistance and hyperinsulinemia

Neurology 51 , 11041109 (1998)

Cochrane Database Syst Rev (10):CD005590 Zhou L, Dhopeshwarkar N, Blumenthal KG, Goss F, Topaz M, Slight SP, Bates DW (2016) Drug allergies documented in electronic health records of a large healthcare system

Like BPC-157, TB-500 has shown promise in preclinical models for soft tissue recovery and chronic injury support but lacks approval for medical application in humans