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First, the effect is enzymatic and cumulative you are shifting a metabolic set-point over days and weeks, not triggering an acute hormonal event, which is why steady daily exposure matters more than any single large dose

"Oral Vitamin B12 Supplementation After Roux-en-Y Gastric Bypass: a Systematic Review"

Ian Musgrave Endurobol (GW501516) : Classified under a group of drugs called peroxisome proliferator-activated receptor (PPAR) agonists, Endurobols potential abuse in athletes is based on animal studies that showed it could improve endurance, increase fat metabolism, improve glucose uptake in skeletal muscle tissue, and increase in muscle gene expression

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