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Concerning signs that require medical attention include: Spreading redness larger than a few inches Red streaks Severe or worsening pain Fever or chills Hives away from the site Facial or throat swelling Any breathing difficulty When symptoms worsen rather than improve, document the site with a photo and contact your clinician promptly so they can assess for infection or a true allergic response

Lussier et al., 2013)

Elevated amino acid levels regulated VGF increase through mTOR-STAT3 signaling activation (Fig

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