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Exogenous IL-1Ra attenuates intestinal mucositis induced by oxaliplatin and 5-fluorouracil through suppression of p53-dependent apoptosis

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The signs of dependence on acetaminophen-opioid drugs are increased tolerance, withdrawal symptoms, and compulsive use despite negative consequences

The effect was dose-dependent, with subcutaneous administration at 15 mg/kg showing significant reductions in fasting glucose and HbA1c markers