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Mitochondrial Biogenesis: The MOTS-c Revolution The mitochondria are no longer viewed simply as "powerhouses" but as signalling hubs that dictate the fate of the cell

BPC 157 inhibits K+ conductance in WT HEK293 cells J Physiol Pharmacol 2009

Content in this block describes receptor-mediated signal generation and experimental observations within laboratory model evaluation

The amyloid-related pathology can be associated with two deleterious mechanisms: (i) the inability of the amyloid-forming protein to perform its native function, termed as loss of function mechanism and (ii) the amyloid deposit itself is to the cellular metabolism, referred as toxic gain of function (Winklhofer et al., 2008)