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This paper describes the loss of capacity to induce LTD in accumbens slices after cocaine self-administration, and raises the possibility that cocaine-induced changes might dissociate synaptic grading from synaptic plasticity

This combination may be particularly relevant in clinical scenarios where monotherapy fails or where adjunct support is necessary to address the metabolic or oxidative dimensions of PCOS

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Satoh method [7]

Topical anesthetic abuse (Fig