glutathione reductase catalytic mechanism catalysis and the reaction mechanisms of glutathione-dependent enzymes The glutathione peroxidase family: Discoveries

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230 By comparing the transcriptomic profile of NSCLC A549 cells exposed to cytotoxic doses of CDDP, cadmium dichloride (CdCl 2 , an environmental pollutant that triggers oxidative stress-dependent apoptosis) and C 2 -ceramide (a plasma membrane permeant ceramide with mitochondriotoxic effects), we have recently demonstrated that CDDP elicits signaling cascades (encompassing both pro-survival and pro-death pathways) that are for the most part private, that is, they manifest limited overlap with the molecular mechanisms set in motion by other inducers of mitochondrial apoptosis

Nanomaterials 12, 2013

Pregnancy and lactation A retrospective observational study reported that daily oral supplementation with 600 mg of lipoic acid (racemic mixture) during pregnancy and without interruption from a period spanning between week 10 and week 30 of gestation and until the end of week 37 was not associated with any adverse effect in mothers and their newborns (114)

However, you will notice a change only after consuming these regularly over time