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Increases in GLT-1 levels and a reduction of chronic ethanol intake following the administration of -lactam antibiotics have also been reported by Sari and associates in rats selected as alcohol drinkers (Rao et al., A number of studies have shown that ASA, even at low anticlotting doses, acutely acetylates cyclooxygenase-1 (Cox-1) in platelets, and chronically, it also acetylates Cox-2 leading to the generation of a powerful anti-inflammatory agent

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It is important to note, since Glx/tNAA indexes the cortical glutamate + glutamine pool rather than synaptic glutamate release alone, the attenuation we observed may reflect metabolic changes as well as altered neurotransmitter cycling, consistent with C-MRS evidence that prefrontal tricarboxylic (TCA)-cycle activity can fall without a corresponding change in glutamate and glutamine cycling in depression 36

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