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Glutathione: New insights into biosynthesis and transport

Molecular dynamics (MD) simulations using platforms like GROMACS or AMBER can elucidate the stability and interaction dynamics of polyphenol candidates (curcumin, EGCG, resveratrol) with ADrelated targets such as amyloid, tau protein, and acetylcholinesterase, leveraging crystallographic data from PDB entries (Gheidari et al

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A 2022 scientific review published in the National Library of Medicine confirmed that nasal delivery of therapeutic peptides is a non-invasive and fast-acting method that can effectively bypass the blood-brain barrier while minimising systemic exposure

The synthesis of GSH from its constituent amino acids involves two ATP-requiring enzymatic steps: (1) the first step is rate-limiting and catalyzed by GCL which is composed of two subunits: one catalytic (GCLC) and one modifier (GCLM): (2) The second step is catalyzed by GSH synthetase (GS) [19]: Although GS is generally thought not to be important in the regulation of GSH synthesis, accumulating evidence suggests that GS may play an important role, at least in certain tissues and/or under stressful conditions [20]