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Correlational evidence has indicated homocysteine levels may be higher in migraine sufferers, especially those who experience migraine with aura, than in healthy individuals (Liampas 2020b)

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Interestingly, exposure of endothelial cells to homocysteine would accelerate the rate of cellular senescence and increase the amount of telomere length lost per population doubling, through a redox-dependent pathway (Xu et al, 2000)