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Several studies underscore that MSC-EVs are generally well-tolerated and exhibit lower immunogenicity compared to their parent cells, enabling safer systemic administration with minimal adverse immune responses [142-144]

The role of non-genetic therapies to reduce the incidence of sickle cell crisis: a systematic review

Avoid unregulated or dubious sources, as they may not contain the stated amounts of glutathione or could pose health risks

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Figure 5 2.2.4 GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4) The GCH1/BH4 pathway is an intracellular enzymatic pathway involved in various crucial cellular metabolic processes (81, 82)