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A highly promising recently developed protocol including marrow reduction and pretransplant immunosuppression, followed by low-intensity conditioning with ATG, has been shown to result in a low risk of toxicity and durable engraftment in class 3 HR patients receiving cells from unrelated and related donors

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Their findings suggest that modifying gut microbiota or supplementing with 3-IAA could serve as promising strategies to enhance the effectiveness of PDAC treatment

This sensitizing effect suggests that AS-IV may help mitigate cisplatin-induced toxicity by reducing the required dosage of the chemotherapeutic agent, thereby alleviating cardiotoxicity during cisplatin therapy