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In lab models, DSIP potentiated GABA-activated currents and affected excitatory signaling, which aligns with its studied calming/sleep-related effects

Based on the above evidence, within the uterine fibroid microenvironment dominated by E 2 and progesterone, OS may exert synergistic effects with hormonal signaling by modulating the activation status of key signaling pathways such as TGF-/Smad3, PI3 K/Akt/mTOR, and MAPK, collectively forming a complex pro-growth signaling network

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