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PrP is a GPI-anchored cell surface glycoprotein that has received considerable attention due to its central role in the pathogenesis of prion disease 16

Due to inhibition of biliary copper excretion it accumulates in hepatocytes, initially bound to metallothionein

Spinules can invaginate nearby spines, axonal boutons, or glial cells, and potentially serve as a mode of localized communication to mediate structural synaptic plasticity (, )

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