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Liou GY, Storz P

Shackebaei et al., 2022)

Recent studies demonstrate that PD-L1 immunotherapy-activated CD8 + T lymphocytes release IFN-, which suppresses expression of the Xc system components SLC3A2 and SLC7A11

The accumulation of these metabolites has been shown to inhibit -KDD activity (most likely due to -KG depletion), thereby promoting stem cell differentiation [107, 108]