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Moreover, despite the considerable pre-clinical efficacy of several pharmacological agents targeting pathological events of hemorrhagic stroke, they failed to perform in clinical trials as factors such as the short half-life periods of agents and the role of the blood-brain barrier (BBB) complicated the scenario (Grysiewicz et al., 2008)

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doi: 10.1038/s41422-022-00653-7 272 TangamornsuksanW.LohitnavyO.SruamsiriR.ChaiyakunaprukN.Norman ScholfieldC.ReisfeldB.et al