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Side Effects, Risks, and Safety Considerations The most common side effects are gastrointestinal nausea, vomiting, and diarrhoea with more serious risks including pancreatitis, gallbladder disease, and elevated resting heart rate

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10.1038/ni.2550 103 MitchellC

doi: 10.1016/j.intimp.2008.10.021

In summary, GPR146 deficiency confers protection against diet-induced obesity, as demonstrated by reduced fat mass, smaller adipocyte size, and lower circulating free fatty acid levels