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Description

Gorczyca, W., Gong, J

In the following diagram the hydrogen bonds are depicted as magenta dashed lines

Even though DOX cannot cross the bloodbrain barrier (BBB), it can cause substantial neurotoxicity with neuronal and synaptic loss, prompting cognitive deficits in the brain [39, 42] In the current work, DOX-induced oxidative stress was proved by higher levels of NOX4 and MDA, accompanied by loss of antioxidant defense mechanisms shown as lower GSH and SOD activities