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Alarmins and immunity

The administration of HMGB1 substantially increased proliferation, migration, collagen secretion, and expression of -SMA, with noteworthy findings indicating that the HMGB1/IL-1 complex significantly elevated the expression and secretion of critical regulatory factors, including TGF-1, MMP-9, and VEGF (263)

Circ-Carm1, highly expressed in oxygen-glucose deprivation/reperfusion (OGD/R)-induced cells, may promote lipid peroxidation and mediate ferroptosis in acute cerebral infarction through the circ-Carm1/miR-3098-3p/ACSL4 axis (Mao and Liu, 2022)