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Such changes in transcriptional output can arise through different routes and depend on both genetic and epigenetic alterations

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Similarly, Cao et al (167) revealed that paeoniflorin (PF) increases the expression levels of PINK1, Parkin, BNIP3, p62 and LC3, which repairs damaged mitochondria by restoring the MMP and clearing accumulated ROS

however, DSMB review of prespecified hepatic events did not identify any confirmed cases of DILI or any liver adverse events related to study drug, and there were no events of liver decompensation

However, weight gain can still enlarge untreated fat cells