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The alkaloids: chemistry and physiology

The rationale stems from evidence that specific micronutrients and bioactive compounds influence biological processes central to BD pathophysiology, including neuroinflammation, oxidative stress, mitochondrial function, and neurotransmitter regulation [11,12]

According to the protein misfolding avoidance hypothesis, natural selection disfavors the misfolding of highly expressed proteins, thereby constraining their evolution to minimize cytotoxicity 38