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The pertinent findings of this study are: 1) enhanced hepatic de novo serine synthesis is required for SAAR to improve glucose tolerance, 2) concurrent with transcriptional activation, a serine synthesis-GSH-lysine lactoylation feedback loop may underlie the increased hepatic serine synthesis in response to SAAR, and 3) hepatic serine synthesis is not necessary for the SAAR-mediated decline in adiposity and liver triglycerides

The FITT Principle (Frequency, Intensity, Type, Time) offers a practical framework to tailor individual exercise plans and enhance adherence

Novel signaling crosstalk between AMP-activated protein kinase (AMPK) and TBC1 domain family member (TBC1D1) reveals additional layers of insulin-independent glucose uptake regulation (316), while tissue-specific microRNA networks, particularly miR-223 and miR-130, regulate complex inflammatory and metabolic responses through post-transcriptional control (310, 317, 318)

A diagnostic injection of the sacroiliac joint with anesthetic should markedly diminish the amount of pain in a specific location of the low back, buttock, or upper leg

The summaries were compiled in both narrative and tabulated formats and circulated to the expert panel for review