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Overall, melatonin's ability to affect multiple pathways involved in the pathophysiology of FM makes it a promising adjunctive treatment for this chronic pain syndrome [66, 67]

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After all, Aristotle wrote in the fourth century BCE that many people, when they want to cool water quickly, begin by putting it in the sun, the benefits of which were presumably noticeable even before the invention of sensitive thermometers

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14 Inclusion criteria required a life expectancy of over one month and a baseline serum sodium 2 mg/dL, hypotension, or patients on vasodilators/inotropes)(baseline characteristics above)