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elegans fail to cross efficiently from the lumen of the intestine into the tissues

Firstly, GA significantly upregulates key drug-metabolizing enzyme genes (e.g., Cyp2b13 , Cyp2c69 , Cyp3a44 , Cyp3a16 , and Fmo3 ) that are downregulated by TGT, thereby enhancing liver detoxification capacity (Shi et al., 2021)

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TLR4 and NFB levels, which were high in PTZ group were also reduced on treatment with Rhein, which also reversed the upregulation of the IKB protein which is an activator of NFB 55